Patient selection: adults with acute tubular necrosis
Risk factors for mortality within 6 months (in multivariate logistic regression):
(1) Apache II score >= 24
(2) oliguria
(3) need for mechanical ventilation
(4) presence of AIDS
(5) presence of 1 or more organ failures in addition to the renal failure (presence of 2 or more organ failures including renal failure)
(6) presence of significant malignancy
Additional risk factors associated with decreased survival:
(1) presence of sepsis
(2) Apache II 19-23 (39% survival at 6 months in the study group)
(3) need for dialysis
Conditions associated with 100% mortality at 6 months after onset of ATN:
(1) Apache II score >= 24
(2) total of 4 or more organ failures
(3) presence of a significant malignancy
