Risk factors for early neurologic deterioration:
(1) elevated D-dimer > 1,900 ng/mL (odds ratio 4.5)
(2) systolic blood pressure > 182 mm Hg (odds ratio 6.8)
Risk factors for mortality:
(1) elevated D-dimer > 1,900 ng/mL (odds ratio 8.8)
(2) intracerebral hemorrhage volume > 30 mL (odds ratio 19)
Limitation:
• The presence of pulmonary embolism or other causes of an elevated D-dimer could cause a false positive interpretation.
• The choice of the d-dimer test performed would affect the best cutoff..
• One of the d-dimer tests in the study was the AutoDimerTest (AGEN, Brisbane, Australia) with a reference range for healthy patients of 360 +/- 670 ng/mL.
• The authors also used the VIDAS d-dimer test (Biomerieux, Lyon, France) with a reference range of 68 to 490 ng/mL.
