Creasman et al evaluated risk factors for lymph node metastases in a woman with endometrial cancer. The authors are from multiple institutions in the United States.
Patient selection: endometrial adenocarcinoma
Parameters:
(1) histologic Grade
(2) pattern of spread
(3) intraperitoneal disease
Grade
Spread
Intraperitoneal Disease
Pelvic Lymph Nodes
Aortic Lymph Nodes
Grade I
endometrium only
none
0%
0%
Grade 2 or 3
endometrium only
none
3%
2%
Grade 1
inner half myometrium
none
3%
2%
Grade 2 or 3
inner half myometrium
none
6%
2%
NA
outer half myometrium
none
18%
15%
NA
inner half myometrium
present
33%
8%
NA
outer half myometrium
present
61%
30%
The first pattern is designated low risk.
The next 3 patterns are designated moderate risk (less than 7%).
The final 3 patterns are designated high risk.
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