Description

Collin et al identified risk factors for death in patients with visceral leishmaniasis (kala-azar) living in the Southern Sudan. Outbreaks of kala-azar have occurred in Southern Sudan with flooding, food shortages and most recently civil war. The authors are from the London School of Hygiene and Tropical Medicine, Northwick Park Hospital and Medecins Sans Frontieres-Holland.


 

Possible correlations between social conflict and poor survival from an infectious disease:

(1) malnutrition and associated compromise of immunity

(2) deterioration in vector control

(3) adequate medical care and medicines not available

 

Risk factors for death in adults with kala-azar:

(1) age >= 45 years

(2) malnutrition (BMI < 13 kg per square meter)

(3) anemia (hemoglobin < 8 g/dL)

(4) duration of illness >= 5 months

 

Risk factors for death in children with kala-azar:

(1) age < 2 years

(2) malnutrition (weight for height < 60% of predicted)

(3) anemia (hemoglobin < 6 g/dL)

(4) splenomegaly (I would expect in most patients with kala-azar)

 

Additional risk factors for death:

(1) diarrhea

(2) vomiting

(3) bleeding

 


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