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Description

Chu and Liaw identified risk factors for cirrhosis developing in a chronic carrier of hepatitis B virus in Taiwan. The authors are from Chang Gung University in Taipei.


 

Initial patient selection - inactive carrier of hepatitis B with history >= 1 year of:

(1) positive HBsAg

(2) negative HBeAg

(3) positive anti-HBe

(4) normal serum ALT levels

 

Risk factors for progression ot cirrhosis:

(1) reactivation of the hepatitis B viral infection (HR 20 in multivariate analysis)

(2) male gender (HR 2.1 in multivariate analysis)

(3) older age (>= 40 years of age)

 

The risk of progression to cirrhosis increased over time after reactivation (after 5 years).

 

Note that these risk factors are in patients with evidence of HBe.

 


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