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Risk Factors of Cheng et al for Locoregional Recurrence (LRR) in Women with T1 or T2 N1M0 Breast Cancer

Description

Cheng et al evaluated women with T1 or T2 primary breast cancers and 1 to 3 involved axillary lymph nodes who were treated with modified radical mastectomy and without adjuvant radiation therapy. They identified risk factors associated with locoregional recurrence (LRR). The authors are from the Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.


 

Parameters identified on univariate analysis:

(1) patient age in years

(2) tumor diameter in cm

(3) estrogen receptor status

(4) lymphovascular invasion

 

Parameter

Finding

Points

age of the patient

< 40 years

1

 

>= 40 years

0

tumor diameter

< 3 cm

0

 

>= 3 cm

1

estrogen receptor status

negative

1

 

positive

0

lymphovascular invasion

negative

0

 

positive

1

 

where:

• An additional risk factors was the absence of tamoxifen therapy.

 

total number of risk factors =

= SUM(points for all 4 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 4

• The higher the score the greater the risk of locoregional recurrence and distant metastases.

• A patient at higher risk of recurrence may benefit from adjuvant radiation therapy with or without tamoxifen therapy.

Total Score

Risk LRR

4 Year LRR rate

0 to 2

low

8%

3 or 4

high

67%

 


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