Cao et al reported prognostic factors for a patient with nasopharyngeal carcinoma metastatic to bone. These can help to identify a patient who may benefit from more aggressive management. The authors are from Sun Yat-sen University in Guangzhou, China.
Patient selection: nasopharyngeal carcinoma with bone metastases
Parameters:
(1) age in years
(2) local recurrence
(3) subsequent metastasis
(4) disease-free interval in months
(5) treatment of bone metastases
Parameter
Finding
Hazard Ratios
age in years
<= 40 years
1
> 40 years
4.79
local recurrence
no
1
yes
7.89
subsequent metastases
no
1
yes
5.71
disease-free interval
<= 24 months
0.29
> 24 months
1
treatment
chemotherapy
0.22
chemoradiation
1
cumulative product of hazard ratios associated with worse survival =
= PRODUCT(HR for all of the parameters)
Interpretation:
• The presence of 3 or 4 higher risk parameters was associated with high risk.
• Survival with chemotherapy tends to be better than survival after chemoradiation.
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