Risk Factors of Arase et al for Development of Diabetes Mellitus in a Patient with Nonalcoholic Fatty Liver Disease (Steatohepatitis)

 

Patient selection: nonalcoholic fatty liver disease (NAFLD) without diabetes

 

Risk factors for the development of diabetes mellitus:

(1) prediabetes

(2) elevated serum GGT (> 109 IU/L)

(3) elevated serum triglyceride concentration (> 150 mg/dL)

(4) physical inactivity (less than 1 hour of physical activity per week)

 

where:

• The odds ratio for prediabetes 6.4 while the other 3 factors had odd ratios from 1.3 to 1.6.

 

Patients who modified their lifestyle with increased physical activity were often able to avoid development of diabetes. These patients:

(1) normalized their blood glucose level

(2) normalized the serum GGT

(3) lowered their serum triglyceride levels