Ahlbrecht et al identified risk factors for venous thromboembolism in a patient with cancer. These can help to identify a patient who may benefit from interventions to reduce the risk. The authors are from the Medical University of Vienna.


Patient selection: carcinoma


Risk factors for venous thromboembolism within 6 months:

(1) tumor grade poorly differentiated or undifferentiated (hazard ratio 1.0)

(2) high risk primary site (gastrointestinal tract, pancreas, lung, kidney; HR 4.3)

(3) adenocarcinoma (HR 2.7)

(4) D-dimer >= 1.32 µg/mL (75th percentile for study population; HR 2.2)



• The elevated D-dimer may not be so much a risk factor as a manifestation of thrombus formation.


The risk of venous thromboembolism increases as the number of risk factors increase.


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