The mortality rate for patients with perforated duodenal ulcer has improved with modern surgical techniques, but some patients still face significant risk. These patients can be identified by the presence of certain risk factors.
Risk factors:
(1) severe medical illness
(2) preoperative shock
(3) longstanding perforation
where:
• Severe medical illness included severe cardiac disease, severe pulmonary disease, renal failure, diabetes mellitus, and hepatic precoma.
• Preoperative shock was defined as a preoperative systolic blood pressure < 100 mm Hg.
• Longstanding perforations were defined as those > 24 hours, because definitive surgery was avoided in these perforations.
Factors not associated with increased mortality in the absence of risk factors above:
(1) old age
(2) gross peritoneal soiling
(3) length of ulcer history
Parameter |
Finding |
Point |
severe medical illness |
present |
1 |
|
absent |
0 |
preoperative shock |
present |
1 |
|
absent |
0 |
longstanding perforation |
> 24 hours |
1 |
|
<= 24 hours |
0 |
risk score =
= number of risk factors present
= SUM(points for 3 risk factors)
discriminant value =
= (3.40 * (points for medical illness)) + (3.12 * (points for shock)) + (0.68 * (points for delay > 24 hours)) - 0.53
Interpretation:
• minimum risk score: 0
• maximum risk score: 3
• minimum discriminant value: -0.53
• maximum discriminant value: 6.67
Values for the discriminant values showed 3 clusters:
(1) neither severe medical illness nor shock: score -0.53 and 0.13: all survived (low risk)
(2) both severe medical illness and shock: 5.99 and 6.67: all died (high risk)
(3) either severe medical illness or shock: 2.59, 2.87, 3.27, 3.55: variable mortality rate somewhere between 10 and 46% (moderate risk)
Specialty: Gastroenterology, Infectious Diseases, Surgery, general