Description

Severe hyperbilirubinemia may develop in a newborn infant if one or more risk factors are present.


 

Neonatal risk factors:

(1) male gender (minor risk)

(2) gestational age 35 to 38 weeks (major at 35-36 weeks; minor at 37-38 weeks)

(3) jaundice present within first 24 hours after delivery (major risk)

(4) jaundice visible before discharge from the hospital (minor risk)

(5) a site of hemorrhage undergoing resorption (extensive bruising, cephalohematoma, other; major risk)

(6) inadequate nutrition and/or dehydration associated with exclusive but suboptimal breastfeeding (major risk)

(7) unrecognized hemolysis (ABO or other blood group incompatibility. G6PD deficiency, other; major risk)

(8) macrosomia associated with maternal diabetes (minor risk)

(9) predischarge serum bilirubin elevated (major if above the 95th percentile; minor if 75 to 95th percentile)

 

Maternal risk factors:

(1) age >= 25 years (minor risk)

 

Familial risk factors

(1) previous affected sibling (major if phototherapy given; minor with jaundice)

(2) race East Asian (major risk)

 

where:

• Being of Mediterranean origin may be a risk factor, but this may reflect hemolytic disease.

 


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