Risk Factors from the NCCN Guidelines for Stratifying Patients with a Well-Differentiated Thyroid Cancer

Description

The National Comprehensive Cancer Network (NCCN) identified factors useful for risk stratification of patients with well-differentiated papillary or follicular thyroid carcinomas. This can help identify those patients who may require more aggressive therapy and closer monitoring.

Patient Factors	High Risk	Low to Moderate Risk
age	< 15 or > 45 years	15 – 45 years
gender	male	female
family history for thyroid cancer	present	absent

Tumor Factors	High Risk	Low to Moderate Risk
diameter	>= 4 cm	< 4 cm
laterality of disease	bilateral	unilateral
extrathyroid extension	present	absent
metastases to cervical lymph nodes	present	absent
metastases to distant sites	present	absent

total number of high risk factors =

= (number of patient factors) + (number of tumor factors)

Interpretation:

• minimum number of factors: 0

• maximum number of factors: 8

• The more risk factors present, the higher the patient risk for recurrence or tumor-related death.

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Risk Factors from the NCCN Guidelines for Stratifying Patients with a Well-Differentiated Thyroid Cancer

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