The Radiation Fibrosis Syndrome (RFS) can be a serious, delayed complication of radiation therapy. Several risk factors can help to identify a patient who may develop this complication.
Patient selection: history of radiation therapy
Risk factors for radiation fibrosis syndrome:
(1) high total ionizing radiation dose
(2) higher dose per fraction
(3) irradiation of a large volume of normal tissue
(4) prolonged radiation therapy
(5) repeated therapy to the same tissue
(6) concurrent chemotherapy
(7) Marfan syndrome
(8) genetic factors making the person more susceptible
(9) type of tissues being irradiated
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