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Risk Factors for Renal Failure Associated with NSAID Use

Specialty:

Nephrology, Urology, Obstetrics & Gynecology, Pedatrics, Genetics
Clinical Laboratory
Clinical Pharmacology & Toxicology

Objective:

ICD-10:

Description:

Nonsteroidal anti-inflammatory drugs (NSAID) may cause renal failure in some patients. NSAIDs decrease the synthesis of renal vasodilator prostaglandins with a decrease in renal blood flow. The presence of certain clinical factors associated with a stimulated renin-angiotensin system may result in an increased risk for developing renal dysfunction which is largely reversible.

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