Several factors have been found associated with poor prognosis in patients with Guillain-Barre Syndrome, even if the patient receives plasmapheresis.


Risk factors for a poor prognosis:

(1) advanced age (> 60 years of age; Barohn et al use > 50-60)

(2) rapid onset prior to presentation

(3) need for mechanical ventilation (Grade 5, Hughes, 1978)

(4) severely reduced distal motor amplitudes (<= 20% of normal)

(5) preceding infections (diarrheal illness with Campylobacter jejuni, cytomegalovirus infection)


Presence of one or more of these risk factors may be associated with a more prolonged course and delayed recovery.


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