A patient taking metformin may be at increased risk for developing lactic acidosis if certain clinical conditions are present.


Risk factors for developing lactic acidosis:

(1) renal dysfunction

(2) hepatic dysfunction

(3) congestive heart failure

(4) excessive alcohol use

(5) moderate to severe dehydration

(6) exposure to radio-opaque contrast media (due to nephrotoxic risk)

(7) surgery

(8) heart attack

(9) stroke

(10) severe infection

(11) other severe systemic inflammatory response

(12) age >= 80 years of age with unknown renal function


Metformin should not be taken if one or more of the above risk factors are present, except as directed by a physician.


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