INH Liver Toxicity Risk Factors | Medical Algorithm

Are you evaluating a patient who is taking isoniazid?

Yes

Age of the patient

years

Gender of the patient

Male

Female

Is/Does the patient?

• pregnant?

Yes

• abuse alcohol?

Yes

• have a chronic liver disease?

Yes

• a slow acetylator?

Yes

• taking a high dose of isoniazid?

Yes

• taking phenobarbital, rifampin, para-aminosalicylic acid or other drug that affects INH metabolism?

Yes

• taking acetaminophen, methotrexate or other drug that is potentially hepatotoxic?

Yes

• malnourished?

Yes

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Data complete?

Evaluation appropriate?

Number of risk factors for isoniazid-induced hepatitis

Is the patient at increased risk for isoniazid-induced hepatitis

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Interpretation and Description

References

Next Steps in Evaluation

Dosage Adjustments
- Monitoring Patient for Evidence of Isoniazid Hepatotoxicity

Adverse Effects
- Monitoring Patient for Evidence of Isoniazid Hepatotoxicity

Evaluation

Results

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Interpretation and Description

References

Next Steps in Evaluation

Therapy

Monitoring

Specialty

Objective

ICD-10

Risk Factors for Isoniazid Hepatotoxicity

Purpose: To identify risk factors for drug-induced hepatotoxicity in a patient taking isoniazid (INH).

Evaluation

Results

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Interpretation and Description

References

Next Steps in Evaluation

Therapy

Monitoring

Specialty

Objective

ICD-10