A number of conditions may predispose a patient to or precipitate an episode of hypoxic liver injury.


Risk factors for hypoxic liver injury:

(1) hypoperfusion of the liver due shock (hemorrhagic, septic, cardiac, other)

(2) hypoperfusion of the liver due to obstruction of portal vein, hepatic vein and/or hepatic artery

(3) hypoxemia secondary to profound anemia, chronic lung disease or carbon monoxide poisoning

(4) heat stroke

(5) cocaine abuse or ergotamine poisoning

(6) cardiac disease with severe right-sided heart failure and/or low cardiac output, including bacterial endocarditis and cardiac arrhythmias

(7) cirrhosis

(8) sickle cell anemia


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