An esophageal stricture may develop in patients following medication-induced esophageal injury, especially if certain risk factors are present.
Risk factors for esophageal strictures:
(1) male gender
(2) older age
(3) left atrial enlargement (compressing the mid-esophagus)
(4) chronic ingestion of sustained release formulation
(5) previous structural or motility abnormality (favoring reduced drug transit)
The presence of a stricture indicates a significant area of fibrosis, which usually involves a relatively large area of injury, typically with ulceration.
The differential diagnosis includes pre-existing stricture found during the workup. An existing stricture can be made worse with superimposed drug injury.
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Specialty: Gastroenterology, Pharmacology, clinical