An esophageal stricture may develop in patients following medication-induced esophageal injury, especially if certain risk factors are present.


Risk factors for esophageal strictures:

(1) male gender

(2) older age

(3) left atrial enlargement (compressing the mid-esophagus)

(4) chronic ingestion of sustained release formulation

(5) previous structural or motility abnormality (favoring reduced drug transit)


The presence of a stricture indicates a significant area of fibrosis, which usually involves a relatively large area of injury, typically with ulceration.


The differential diagnosis includes pre-existing stricture found during the workup. An existing stricture can be made worse with superimposed drug injury.


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