Particulate material may occasionally be noticed in blood products. The type of particulate is important to determine.


Types of endogenous particulates:

(1) white blood cell aggregates

(2) platelet aggregates

(3) cold agglutinins


Risk factors for formation of white blood cell aggregates (Patel et al):

(1) heavy centrifugation during preparation of components (5,000 g)

(2) donors with elevated total cholesterol (> 195 mg/dL)


Differential diagnosis:

(1) precipitate of additives to the blood collection bags

(2) bacterial or fungal contamination

(3) drug injected into product


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