A variety of factors may increase the risk of endometrial adenocarcinoma in women. Many of the factors are associated with endometrial hyperplasia, often due to estrogenic stimulation.
Parameter
Finding
Risk Increase
obesity
30 - 49 pounds
3.0
>= 50 pounds
10.0
parity
nulliparity
2.0
menopause
late occurring
2.4
hemorrhagic ("bloody")
4.0
diabetes mellitus
2.8
hypertension
1.5
estrogen-related
unopposed estrogen replacement
4 to 8
tamoxifen
6.4 (page 300)
endometrial hyperplasia
complex atypical hyperplasia
29.0
Combination of a progestin with estrogen will reduce the hyperplastic influence of unopposed estrogen.
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