Myelinolysis is more likely to occur if certain risk factors are present. Awareness of the risk factors can help prevent occurrence of this serious neurologic disorder.


Risk factors:

(1) hyponatremia for > 48 hours

(2) saline infusions causing an increase in serum sodium > 8 mmol/L per day in a patient with chronic hyponatremia

(3) presence of chronic liver disease in a patient with hyponatremia

(4) history of orthotopic liver transplantation in a patient with hyponatremia



• I am not sure if the risk for patients following orthotopic liver transplants is independent of the hyponatremia.


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