Colistin may be used to treat infections caused by extensively drug-resistant Gram-negative bacteria. Nephrotoxicity is a limiting factor for its use. A number of factors may contribute to nephrotoxicity.
Nephrotoxicity was defined as >= 2 fold increase in the serum creatinine concentration from baseline.
Risk factors for nephrotoxicity include:
(1) older age
(2) hypoalbuminemia
(3) concurrent therapy with glycopeptide or other nephrotoxin
(4) GFR < 60 mL per minute per 1.73 square meter AND high dose of colistin (>= 2.87 mg per day per kilogram of ideal body weight)
(5) anemia
To read more or access our algorithms and calculators, please log in or register.
