A number of factors may increase neurotoxicity of bilirubin in a neonate. A neonate with one or more risk factors may benefit from more aggressive management of hyperbilirubinemia.

Risk factors for bilirubin neurotoxicity:
(1) isoimmune hemolytic anemia (anti-D, anti-ABO, etc)
(2) glucose-6 phosphatase deficiency (G6PD)
(3) asphyxia
(4) sepsis
(5) acidosis
(6) serum albumin < 3.0 g/dL

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