Adenomatous endometrial hyperplasia tends to occur with excessive or unopposed estrogenic stimulation of the endometrium. It may be associated with excessive bleeding and may precede the development of adenocarcinoma. Identification of women at risk can aid in diagnosis and early intervention.


Risk factors for postmenopausal women:

(1) noncontraceptive, unopposed estrogen use, especially long-term (> 60 months)

(2) heavy body weight (Quetelet index > 2.9 g per cm^2)

Risk Factor

Adjusted Odds Ratio

noncontraceptive estrogen use


estrogen use > 60 months

> 20

high Quetelet index


from Table 3, page 296


Risk factors for premenopausal women:

(1) irregular menstrual cycles for the previous 5 years

(2) heavy menstrual flow for the previous 5 years

(3) high economic income

(4) heavy body weight by itself (Quetelet index > 2.9 g per cm^2) had somewhat of a protective effect


Risk Factor

Adjusted Odds Ratio

irregular menstrual cycles


heavy menstrual bleeding


economic income


high Quetelet index


from Table 6, page 298


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