Acute renal failure can occur during the course of malaria for a variety of reasons. These can result in acute tubular necrosis (ATN), glomerulonephritis, and other renal injuries.
Risk factors associated with acute renal failure:
(1) hemolysis (including G6PD-related hemolysis)
(2) rhabdomyolysis
(3) therapy with a nephrotoxic drug
(4) dehydration
(5) DIC
(6) severe malaria with hyperparasitemia, hypotension and multi-organ failure
Early and aggressive therapy of the renal failure can be life-saving. Hemodialysis may be more efficient than peritoneal dialysis, especially in severe malaria.
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