Molar-Incisor Hypomineralization (MIH) is a poorly understood disorder attributed to disrupted ameloblastic function during the formation of the permanent dentition. A number of conditions have been implicated as predisposing factors but none have been conclusively proven.


Perinatal theory:

(1) maternal febrile illness in the perinatal period

(2) complications before or during birth

(3) preterm birth


Childhood illness theory:

(1) high fever during infancy

(2) hypoxemia (due to asthma or other respiratory disorder)

(3) frequent illness during the first four years of life

(4) hypocalcemia


Toxin exposure theory:

(1) chemicals in breast milk

(2) antibiotic exposure

(3) other medications given during infancy


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