Molar-Incisor Hypomineralization (MIH) is a poorly understood disorder attributed to disrupted ameloblastic function during the formation of the permanent dentition. A number of conditions have been implicated as predisposing factors but none have been conclusively proven.
Perinatal theory:
(1) maternal febrile illness in the perinatal period
(2) complications before or during birth
(3) preterm birth
Childhood illness theory:
(1) high fever during infancy
(2) hypoxemia (due to asthma or other respiratory disorder)
(3) frequent illness during the first four years of life
(4) hypocalcemia
Toxin exposure theory:
(1) chemicals in breast milk
(2) antibiotic exposure
(3) other medications given during infancy
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