Gofrit et al identified factors associated with a higher Gleason score being found in a prostatectomy specimen compared to that reported in the needle biopsies. The authors are from the University of Chicago.
Patient selection: Gleason score 6 (3 + 3)
Parameters:
(1) serum PSA in ng/mL
(2) age of the patient in years
(3) maximum percent of cancer in a single needle core
Serum PSA
Percent Cancer in a Core
Age of the Patient
Percent Upgraded
> 12.15
NA
NA
62%
<= 12.15
<= 5.5%
<= 66.5
7%
<= 12.15
<= 5.5%
> 66.5
41%
<= 12.15
> 5.5%
<= 47.5
0%
<= 12.15
> 5.5%
> 47.5
24%
where:
• The cutoffs appear to be computer generated.
• Many patients will fall into the last group since the age range is so large.
Limitations:
• The analytical method and reference range for the serum PSA test is not stated.
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