Yoon et al evaluated patients with acute myeloid leukemia (AML). They used age, performance status and comorbidity to stratify patients by risk with selection of a therapy appropriate for the level of risk. The authors are from The Catholic University of Korea in Seoul.
Patient selection: older adult (age > 60 years) with AML
Parameters:
(1) age in years
(2) ECOG performance status
(3) comorbidity index (Charlson or hematopoietic cell transplantation specific comorbidity index (HCT-CI of Sorror et al), with a score >= 2 considered significant (moderate or severe)
Age in Years
ECOG
Comorbidity
Risk
<= 65 (61 to 65)
0 or 1
0 or 1
low
NA
3 or 4
NA
high
NA
NA
>= 2
high
NA
2
0 or 1
intermediate
> 65
0 or 1
0 or 1
intermediate
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