The RIFLE (risk, injury, failure, loss, end-stage) classification can be used to describe the severity of renal injury.
Acute renal injury should be both:
(1) abrupt (within 1 to 7 days)
(2) sustained (lasting more than 24 hours)
Acute renal injury - based on the worse of glomerular filtration rate (GFR) and urine output criteria
(1) risk (R)
(2) injury (I)
(3) failure (F)
Serum Creatinine (GFR criteria) |
Class |
1.5 to 1.99 times baseline |
risk |
2 to 2.99 times baseline |
injury |
>= 3 times baseline |
failure |
>= 4 mg/dL with acute rise > 0.5 mg/dL |
failure |
where:
• GFR is calculated from serum creatinine using the MDRD equation.
Urine Output |
Class |
< 0.5 mL per kg per hour for 6+ hours |
risk |
< 0.5 mL per kg per hour for 12+ hours |
injury |
< 0.3 mL per kg per hour for 24+ hours |
failure |
anuria for 12+ hours |
failure |
Chronic renal injury:
(4) loss (L): complete loss of renal function > 4 weeks (persistent ARF)
(5) end-stage (E): end stage renal disease for > 3 months
Specialty: Nephrology, Clinical Laboratory
ICD-10: ,