The RIFLE (risk, injury, failure, loss, end-stage) classification can be used to describe the severity of renal injury.
Acute renal injury should be both:
(1) abrupt (within 1 to 7 days)
(2) sustained (lasting more than 24 hours)
Acute renal injury - based on the worse of glomerular filtration rate (GFR) and urine output criteria
(1) risk (R)
(2) injury (I)
(3) failure (F)
Serum Creatinine (GFR criteria)
1.5 to 1.99 times baseline
2 to 2.99 times baseline
>= 3 times baseline
>= 4 mg/dL with acute rise > 0.5 mg/dL
• GFR is calculated from serum creatinine using the MDRD equation.
< 0.5 mL per kg per hour for 6+ hours
< 0.5 mL per kg per hour for 12+ hours
< 0.3 mL per kg per hour for 24+ hours
anuria for 12+ hours
Chronic renal injury:
(4) loss (L): complete loss of renal function > 4 weeks (persistent ARF)
(5) end-stage (E): end stage renal disease for > 3 months
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Specialty: Nephrology, Clinical Laboratory