Description

Leise et al reported several revisions to MELD (model for end-stage liver disease) which optimize the prediction of short-mortality for patients awaiting liver transplant. The authors are from the Mayo Clinic.


Patient selection: liver transplantation waiting list

 

Outcome: 90-day mortality

 

Parameters:

(1) serum total bilirubin in mg/dL

(2) serum creatinine in mg/dL

(3) INR

 

Constraints on parameters:

(1) minimum bilirubin: 1 mg/dL

(2) minimum creatinine: 0.8 mg/dL

(3) maximum creatinine: 3 mg/dL

(4) minimum INR 1

(5) maximum INR: 3

 

Other adjustments: renal replacement therapy defined as creatinine of 3 mg/dL

 

refitted MELD score =

= (4.082 * LN(bilirubin)) + (8.484 * LN (creatinine)) + (10.671 * LN(INR)) + 7.432


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