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Revised International Prognostic Score for Waldenstrom's Macroglobulinemia. Leukemia (rIPSSWM)

Description

Kastritis et al reported a revised International Prognostic Score for patients with Waldenstrom's macroglobulinemia (rIPSSWM). This is a simple score determining a patient's prognosis. The authors are from multiple institutions in Europe.


Patient selection: Waldenstrom's macroglobulinemia

 

Parameters:

(1) age in years

(2) serum beta-2 microglobulin in mg/L

(3) serum LDH in IU/L

(4) serum albumin in g/dL

 

Parameter

Finding

Points

age in years

<= 65 years

0

 

66 to 75 years

1

 

> 75 years

2

beta-2 microglobulin

<= 4 mg/L

0

 

> 4 mg/L

1

LDH

<= 250 IU/L

0

 

> 250 IU/L

1

serum albumin

>= 3.5 g/dL

0

 

< 3.5 g/dL

1

 

total score =

= SUM(points for all of the parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 5

 

Score

Risk Group

5-Year Overall Survival

0

very low

95%

1

low

86%

2

intermediate

78%

3

high

47%

4 or 5

very high

36%

 


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