Patient selection: primary myelofibrosis
Categories of risk: favorable, unfavorable and very high risk
Favorable risk:
Normal karyotype
Sole 20q−
Sole 13q−
Sole +9
Sole –Y
Sole sex chromosome abnormality
Sole chromosome 1 translocation/duplication
Unfavorable risk:
Sole +8
Sole 7q−
Sole translocations not involving chromosome 1
Two abnormalities not including a VHR abnormality
Single/multiple 5q− abnormalities
Complex karyotype without a VHR abnormality
Monosomal karyotype without a VHR abnormality
Sole abnormalities not otherwise classified
Very high risk (VHR):
Single/multiple monosomy 7
Single/multiple inv(3)/3q21 abnormalities
Single/multiple i(17q) abnormalities
Single/multiple 12p−/12p11.2 abnormalities
Single/multiple 11q−/11q23 abnormalities
Single/multiple autosomal trisomies other than +8 or +9 (e.g., +21, +19)
