Revised Criteria of Corpechot et al for Biochemical Response to Therapy with Ursodeoxycholic Acid (UDCA) in a Patient with Primary Biliary Cirrhosis (Paris II Criteria)

Description

Corpechot et al refined criteria for a biochemical response to therapy with ursodeoxcholic acid (UDCA) in a patient with primary biliary cirrhosis (PBC). The authors are from Hoital Saint-Antoine Publique-Hopitaux de Paris and Universite Pierre et Marie Curie in Paris.

Patient selection: primary biliary cirrhosis after 1 year of ursodeoxycholic acid (UDCA) therapy

Early PBC was defined as both normal serum total bilirubin and serum albumin concentrations at baseline.

Parameters:

(1) serum alkaline phosphatase as multiple of upper limit of normal (ULN)

(2) serum AST as multiple of upper limit of normal (ULN)

(3) serum total bilirubin in mg/dL

Serum Alkaline Phosphatase	Serum AST	Serum Total Bilirubin	Response Term
<= 2 * ULN	<= 2 * ULN	normal	Paris IIa
<= 1.5 * ULN	<= 1.5 * ULN	normal	Paris IIb
normal	normal	normal	Paris IIc

The most accurate metric for response over several years was the Paris IIb criteria.

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Revised Criteria of Corpechot et al for Biochemical Response to Therapy with Ursodeoxycholic Acid (UDCA) in a Patient with Primary Biliary Cirrhosis (Paris II Criteria)

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