Some patients with a disorder of connective tissue may be at increased risk for retinal detachment.

Retinal detachment has been reported for:

(1) Stickler syndrome (more common): mutations in COL2A1 and COL11A1

(2) Ehlers-Danlos syndrome: types IV and VI


Clinical features may include:

(1) family history of retinal detachment

(2) family history of a connective tissue disorder

(3) physical stigmata of connective tissue disorder

(4) retinal detachment after minor trauma

(5) onset during childhood

(6) bilateral retinal detachment

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