Restrictive Allograft Syndrome (RAS) is one kind of chronic lung allograft dysfunction that may develop after lung transplantation.


Criteria for RAS – both of the following:

(1) irreversible decline in total lung capacity (TLC) to < 90% of baseline

(2) irreversible decline in FEV1 to < 80% of baseline (= chronic lung allograft dysfunction)


There is a restrictive pattern of pulmonary function decline.


Histologic findings seen in RAS include:

(1) pleuroparenchymal fibroelastosis

(2) diffuse alveolar damage (DAD)

(3) obliterative bronchiolitis


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