Brix et al reported a simple score for predicting renal risk in a patient with ANCA-associated glomerulonephritis. The authors are from multiple institutions in Germany and Switzerland.
Patient selection: ANCA-associated glomerulonephritis
Outcome: end-stage renal disease (ESRD) within 3 years
Parameters:
(1) percent normal glomeruli
(2) percent tubular atrophy and interstitial fibrosis
(3) GFR at the time of diagnosis in mL per min per 1.73 square meter
Parameter
Finding
Points
percent normal glomeruli
> 25% (N0)
0
10 to 25% (N1)
4
< 10% (N2)
6
percent atrophy and interstitial fibrosis
<= 25% (T0)
> 25% (T1)
2
GFR at diagnosis
> 15 mL per min per 1.73 square meter
<= 15
3
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 11
• The higher the score the greater the risk for ESRD.
Total Score
Risk Group
3-Year ESRD
low
0%
2 to 7
medium
16% (Figure 5b)
8 to 11
high
68-78%
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Specialty: Nephrology, Immunology/Rheumatology
