Lipemia may interfere with a number of laboratory tests. There are a number of methods to remove this interference, but each method has its pros and cons.
Methods of removing lipemic interference:
(1) centrifugation
(2) extraction and removal of the lipid with polar solvent (Lipoclear, other)
(3) dilution
Method
Pros
Cons
centrifugation
effectively removes lipids and allows further testing of many analytes
lack of availability of ultracentrifuge, lipid soluble compounds removed
extraction
removes lipids allowing testing of cleared specimen
lipid soluble compounds removed, chemicals may interfere with some analytes
dilution
allows measurement of lipid soluble compounds
compounds at a low concentration may be diluted below the analytical level of detection, errors in making dilutions or calculations
where:
• Verification studies should be performed with extraction methods to make sure that there is no interference with analytical methods.
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