Alvarez-Twose et al reported a score for predicting a clonal mast cell disorder in a patient with symptoms of systemic mast cell activation. The authors are from Hospital Virgen del Valle in Toledo, Spain.
The Spanish Network of Mastocytosis is known as REMA.
Parameters:
(1) sex
(2) urticaria, pruritis and/or angioedema
(3) presyncope and/or syncope
(4) serum tryptase at baseline
Parameter
Finding
Points
sex
male
1
female
-1
urticaria, pruritis and/or angioedema
none
1
any
-2
presyncope and/or syncope
no
0
yes
3
serum tryptase
< 15 ng/mL
-1
15 to 25 ng/mL
0
> 25 ng/mL
2
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: -4
• maximum score: 7
• A score < 2 is associated with a low probability of clonal MCAD.
• A score >= 2 is associated with a high probability of clonal MCAD
Performance:
• The sensitivity was 0.92 and specificity 0.81.
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