Refractory Familial Mediterranean Fever (FMF)

Patient selection: Familial Mediterranean Fever (FMF)

Criteria for FMF refractory to colchicine:

(1) >= 1 attack per month

(2) receiving maximally tolerated colchicine dose of therapy for >= 6 months

(3) patient compliant with therapy

Additional measures for response to therapy:

(1) FMF50 score (at least 50% improvement in 5 out of 6 criteria by 3-6 months with no worsening in any criteria)

(2) autoinflammatory disease activity index (AIDAI)

(3) autoinflammatory disease damage index (ADDI)

Additional outcomes of concern other than clinical attacks:

(1) ongoing subclinical inflammation with ongoing deposition of amyloid protein