Sharma et al reported the ReDRESS score to predict recurrence of DRESS syndrome. The authors are from the University of California Irvine and the University of Southern California.
Patient selection: history of DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms)
Parameters:
(1) sex
(2) rash morphology
(3) facial edema
(4) ANA status
(5) medication class
(6) age in years
Parameter
Finding
Points
sex
female
0
male
-7.6076
rash morphology
erythroderma
0
maculopapular or morbilliform
-1.5884
other
0
facial edema
no
0
yes
-1.8032
ANA status
no
0
yes
4.4831
medication class
antibiotic
-2.8892
antigout
-2.8892
antiseizure
-2.8892
other
0
age
-0.1017 * (age)
total score =
= SUM(points for all of the parameters) + 6.35
Interpretation:
• A total risk score > 0.20 was associated with a high risk of recurrence.
• Although the score is based on a logistic regression model, usage suggests that the decision is based on the sum of the parameters rather than calculating the probability.
Performance:
• The area under the ROC curve is 0.87.
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