Fragkandrea et al reported a number of physical findings that may be red flags identifying a pediatric patient with an underlying malignancy. These can help to identify a patient who may benefit from a more in-depth evaluation. The authors are from The Royal Marsden Hospital, Epsom and St. Helier NHS University Hospital, and Panagiotis and Aglaia Kyriakou Children’s Hospital in Athens.
Patient selection: pediatric
Findings involving skin and mucous membranes that may be red flags for an occult malignancy:
(1) petechiae and/or ecchymoses
(2) recurrent epistaxis
(3) bleeding gums
(4) recent appearance of subcutaneous nodules or masses
(5) palpable mass that is nontender and hard
(6) palpable mass associated with lymphadenopathy
(7) eczematoid rash unresponsive to conventional therapy
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