Certain clinical findings may indicate the presence of Hirschsprung's disease in a patient.


Clinical findings:

(1) delayed passage of meconium after birth (> 24 hours)

(2) constipation starting as a neonate

(3) positive family history (affected sibling)

(4) poor growth (failure to thrive)

(5) abdominal ditention

(6) chromosomal anomaly (Down's syndrome, other)


The differential diagnosis includes functional constipation which may have one or more of the clinical findings.

Number of Findings

Frequency in Patients with Hirschsprung's Disease


Few (< 1 %)

1 or 2


3 to 6



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