Tran and Anand proposed regimens of oral antiplatelet drugs for patients with stable coronary artery disease. Effective oral antiplatelet therapy can help reduce ischemic events in these patients.
Parameters:
(1) initial choice of oral antiplatelet therapy
(2) occurrence of TIA or stroke
(3) occurrence of an acute coronary syndrome (ACS)
Initial choice of oral antiplatelet therapy can either be:
(1) aspirin
(2) clopidogrel
Factors that may be considered in initial choice:
(1) allergic reactions to aspirin
(2) cost
(3) aspirin resistance
Indications for switching to aspirin + clopidogrel:
(1) TIA/stroke
(2) acute coronary syndrome
Exception: initial drug aspirin and TIA/stroke (see below)
Alternatives to aspirin + clopidogrel:
Initial Drug
Subsequent Disorder
Alternative Drug
aspirin
TIA/stroke
clopidogrel
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