An infant or young child with feeding difficulties may have agenesis of the corpus callosum. Agenesis of the corpus callosum can result in a spectrum of findings, ranging from none to severe.


Findings that may be seen in a pediatric patient with agenesis of the corpus callosum:

(1) neurological abnormalities (seizures, hypotonia, temperature instability, developmental delay or mental retardation)

(2) multiple dysmorphic features

(3) prominent oral-sensory defensiveness with avoidance of sensory stimulation around the mouth and lips. This may be limited to certain foods or liquids.

(4) oral motor weakness causing significant dysphagia during the oral and pharyngeal phases of swallowing, which may be associated with pulmonary aspiration


The patient may be able to feed but only using a particular bottle or nipple.


The patient may have a history of feeding tube placement, but the feeding problems cannot be explained by this intervention.


The diagnosis can be made by appropriate imaging of the corpus callosum.


Oral-sensory desensitization can be performed to increase the tolerance of the child to various stimuli. This may involve a series of exposures over time, such as vibration, brushing, chewing exercises and tactile exposures.


To read more or access our algorithms and calculators, please log in or register.