Poh et al reported the Real-World Risk Score for hepatocellular carcinoma (RWS-HCC) for identifying a patient with chronic hepatitis B virus who is at risk for hepatocellular carcinoma. The authors are from Singapore General Hospital, Academia Sinica (Taipei), National Yang-Ming University, The University of Hong Kong, The Chinese University of Hong Kong and National Taiwan University.
Patient selection: chronic hepatitis B virus
Parameters:
(1) sex
(2) age in years
(3) cirrhosis
(4) serum alphafetoprotein in µg/L
Parameters
Finding
Points
sex
female
0
male
2
age in years
<= 55 years
0
> 55 years
1
cirrhosis
absent
0
present
2.5
serum AFP
< 4.1 µg/L
0
4.1 to 20 µg/L
2
> 20 µg/L
2.5
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 8
• A score < 4.5 is associated with a very low rate of hepatocellular carcinoma.
• A score >= 4.5 was associated with a continuous increase in risk for hepatocellular carcinma, with a 20% probability at 6 years.
Performance:
• The area under the ROC cure was 0.915.
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