Sorbitol may be present as an excipient in drug preparations. A patient with hereditary fructose intolerance may have a serious reaction to sorbitol.

Patient selection: hereditary fructose intolerance


Risk factors:

(1) exposure to a large amount of sorbitol (PRAXBIND contains 4 grams per dose)

(2) intravascular infusion


Adverse effects that may occur:

(1) hypoglycemia

(2) hypophosphatemia

(3) metabolic acidosis

(4) hyperuricemia

(5) acute liver failure

(6) death

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