Jaybose et al reported the RDW index (RDWI) as a method of distinguishing iron deficiency anemia from thalassemia trait. The authors are from New York Medical College in Valhalla.
Patient selection: mild microcytic anemia (hemoglobin >= 8.0 g/dL)
(1) MCV in femtoliters
(2) RBC in 10^12/L
(3) RDW in percent
RDW index =
= ((MCV) / (RBC)) * (RDW)
• Hoffman et al uses (MCV) / ((RBC) * (RDW)) but this gives poor results.
• A score > 220 is associated with iron deficiency anemia.
• A score < 220 is associated with thalassemia trait.
• The sensitivity was 91% and specificity 91% for diagnosis of iron deficiency anemia.
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Specialty: Hematology Oncology