Clinical features of Raynaud's phenomenon:
(1) Vasospasm may be precipitated by exposure to cold, dampness or vibration.
(2) The skin undergoes a sequence of changes, initially with pallor and/or cyanosis followed by erythema
(3) The changes may be accompanied by numbness, tingling, burning or pain.
Sites of involvement may include:
(1) acral sites, especially fingers and toes
(2) exposed facial skin (ear lobes, nose)
(3) penis or scrotum
The erectile dysfunction associated with Raynaud's phenomenon is vasculogenic, associated with the recurrent episodes of vasospasm. Recurrent episodes of vasospasm can result in fibrosis and permanent damage.
Diseases associated with Raynaud's disease may include:
(1) scleroderma (systemic sclerosis)
(2) Rheumatoid Arthritis (RA)
(3) SLE
(4) Sjogren's syndrome
(5) chemotherapy-induced angiopathy
(6) vibration-induced
(7) hypothyroidism
(8) uremia
(9) cervical rib
(10) familial
(11) drug-induced
(12) idiopathic
Many of the conditions associated with Raynaud's phenomenon have other reasons for erectile dysfunction.
