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Ratio of Urinary 6-Beta-Hydroxycortisol to Cortisol to Phenotype CYP3A4 Activity

Specialty:

Clinical Pharmacology & Toxicology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care

Objective:

ICD-10:

Description:

The ratio of urinary 6-beta-hydroxycortisol to urinary cortisol can serve as a phenotypic marker of CYP3A4 activity. An increase in the ratio from baseline indicates enzyme induction, while a decrease indicates enzyme inhibition.

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